Greek mythology, a phoenix or phenix (Greek:
φοῖνιξ phoinix; Latin: phoenix, phœnix, fenix) is a
long-lived bird that is cyclically regenerated or reborn
PHENIX (PHENotype Imputation eXpediated) is the name of our method for imputing missing phenotypes where samples have an arbitrary level of relatedness. The method can also be used for dimensionality reduction of multiple traits in related samples. The resulting latent traits can be tested as phenotypes, and can result in an increase in power.
The method is described in detail in this paper
Andrew Dahl, Valentina Iotchkova, Amelie Baud, Åsa Johansson, Ulf Gyllensten, Nicole Soranzo, Richard Mott, Andreas Kranis, Jonathan Marchini. A multiple phenotype imputation method for genetic studies. Nature Genetics
We have made available an R package that implements this method for non-commercial use only.
Please read this licence here
Current version : phenix_1.0.tar.gz [User Manual]
A related paper on modelling multiple phenotypes is
Andy Dahl, Victoria Hore, Valentina Iotchkova, Jonathan Marchini (2013). Network inference in matrix-variate Gaussian models with non-independent noise.
We are developing methods for Bayesian Sparse multi-trait GWAS in related and unrelated samples.